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Laboratory

LRGK – Laboratory of Genomics and Radioiology of Keratinopoiesis

CEA – Laboratoire de Génomique et Radiobiologie de la Kératinopïèse – DSV – Genopole Campus 2 – Bâtiment G2 – 2 rue Gaston-Crémieux – CP 5722
91057 EVRY Cedex
Phone : +33 1 60 87 83 44

Email : nicolas.fortunel@cea.fr

Director : FORTUNEL Nicolas
Web Site (french) >

#Genomics / Postgenomics #Biotherapies #Synthetic Biology #Systes Biology

  • Human cutaneous biology
  • Genomics
  • Stemness genes
  • Regenerative medicine
  • Radiobiology
  • Cancer

Supervisors:

CEA

Inserm - tutelle de laboratoires génopolitainsUniversité Paris-Saclay - tutelle de laboratoire génopolitain

Field of Activity

Basic research on skin stem cells, their genetic determinants and their sensitivity to genotoxic agents (UV and RI); Applications: Healing, cutaneous carcinogenesis
– Stem cell biology.
– Cell therapy.
– Cancer.
– Radiosensitivity.

The Genomics and Radiobiology of Keratinopoiesis Laboratory (LGRK) is part of the CEA’s François Jacob Institute of Biology.
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.

  • The first objective of the laboratory’s team is to characterize the properties of these cells in their normal state. The team seeks to identify the determinants of the stem-cell state and the self-renewal of stem keratinocytes, notably as concerns TGF-B1 regulatory pathways.
  • A second objective is to study these stem cells in pathological conditions. The team studies the role of stem keratinocytes in skin cancers (under ionizing radiation and UV light) and certain pathologies associated with rare dermatological disorders causing hypersensitivity to genotoxic agents, particularly Gorlin syndrome.
  • COLLABORATION / CHAIR

    The laboratory participates in programs associated with the ANR, the Investissements d’avenir program and a number of European networks (RISK-IR, Euratom). It is also involved in a range of collaborative projects :

    • some academic, with the CNRGH, I-Stem, Genethon or IRBA (in Brétigny-sur-Orge).
    • others clinical, with the Percy Hospital, Institut Curie (Paris) or Inserm U916 (Bordeaux).
    • a few industrial, with METAFORA Biosystems or Texcell.
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With the support from
Région île de France
Ministère de l'Enseignement supérieur et de la recherche AFM-Téléthon
Communauté d'agglomération Grand Paris Sud
Département de l'Essonne - Terre D'avenirs Ville d'Evry-Courcouronnes 2023 CEA Inserm Centre hospitalier Sud Francilien Université d'Evry - Paris Saclay Université PAris-Saclay SEM Genopole

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