#Genomics / Postgenomics
- Biochemistry, Biocatalysis, Bioremediation
- Metabolism, Metabolomics
- Comparative genomics, Functional genomics
- Mass spectrometry
- Synthetic biology
- Metabolic engineering
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#Genomics / Postgenomics
Study of the chemistry and the diversity of organisms.
Genomics of eukaryotes, prokaryotes and metagenomes.
The Metabolic Genomics Laboratory (UMR 8030) is the basic research structure of the Genoscope-National Sequencing Center (see page 25), which is fully integrated in the CEA’s François Jacob Institute of Biology.
Through our own projects or those undertaken in collaboration with national and international partners, we analyze genomes to explore the biodiversity of organisms and thus contribute significantly to a more complete understanding of life in all its complexity. New sequencing techniques have profoundly changed genomic research by making access to sequencing data commonplace and by extending sequencing knowledge to cover all biodiversity. Particularly, a flagship project, involving the sequencing bioinformatics analysis team (P. Wincker), is underway to explore the biodiversity of ocean life (Tara Oceans).
This flood of de novo sequencing data has also accelerated growth in the number of identified genes whose purpose is currently a mystery. Genoscope and UMR have thus decided to extend their biodiversity focus to the study of the chemical reactions of organisms, and structure the unit into three scientific groups:
Beyond its interest in fundamental research, the exploration of the chemistry of life based on the discovery and use of enzymes (“white biotech”) will contribute greatly to inventing new ways of producing compounds of-interest. It also participates in the development of sustainable chemistry by contributing to the deployment of chemistry processes that require less fossil fuels, lower energy needs and reduce pollution.
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ART-TG is a pre-GMP stage R&D laboratory aiming to bridge a gap between research and clinical or industrial applications. It has pharmaceutical expertise for product development and product manufacturing, specifically for genomic therapy approaches.Discover
The institute evaluates the therapeutic potential of all types of stem cells in the setting of monogenic diseases.Discover
Gene therapy for rare genetic diseases. Research, preclinical and clinical development of gene therapies for neuromuscular and other rare genetic diseases.Discover
Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.Discover
The Integrare research unit aims to develop effective and safe gene therapies for rare genetic diseases such as neuromuscular disorders, metabolic diseases or blood/immune disordersDiscover
Genomics and postgenomics of biodiversity – Metagenomics of microorganisms from the environment.Discover
Genomics – Genetic Statistics Research on genetic susceptibility to complex diseases through genomic analyses with a focus on rheumatoid arthritis.Discover
Plant genomics. Detection, analysis and management of plant species polymorphism.Discover
The CNRGH is a national-level center whose mission is to provide high throughput genotyping and sequencing services with the objective of optimizing genetic and genomic research for human diseases.Discover