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Laboratoire

INTEGRARE – Integrated genetic approaches and new therapies for rare diseases


Pôle de Recherche de Généthon, 1 bis rue de l’Internationale, BP 60
91002 EVRY cedex – FRANCE
Phone : +33 1 69 47 34 40
Email : galy@genethon.fr

Manager : GALY Anne
Web Site (french) >

#Genomics / Postgenomics #Biotherapies #Synthetic biology #Systems Biology

  • Gene therapy
  • Rare diseases, Immunodeficiency, Wiskott-Aldrich syndrome, Chronic granulomatous disease, Fanconi anemia, Muscular dystrophies, Myotubular myopathy, Limb-girdle muscular dystrophy, Crigler-Najjar syndrome
  • Clinical trials
  • Hematopoietic stem cells
  • Liver
  • Lentiviral vectors, Adeno-associated virus vectors
  • CRISPR-Cas9
  • Imaging cytometry

Supervisions :

Inserm - supervision of Genopole's laboratoriesUEVE - supervision of Genopole's laboratories

Field of Activity


Gene therapy, biotherapies, rare diseases.

– Treatment and study of genetic immune, blood, muscular or metabolic diseases.
– Study of therapeutic host/ vector interactions, particularly within the immune system.
-Technological innovation, genomic and cellular targeting.

The Integrare research unit aims to develop effective and safe gene therapies for rare genetic diseases such as neuromuscular disorders, metabolic diseases or blood/immune disorders. Various gene correction strategies are used, including viral vectors and genome editing, which are studied in pathophysiological contexts. Collaborations are established to translate research results towards early-phase clinical trials in France and at the international level. The Integrare research unit of Genethon is affiliated with Inserm, University of Evry and Université Paris Saclay and EPHE.

INTEGRARE’s projects enable :

  • the development of clinical applications;
  • a better understanding of the biology and pathophysiology of the diseases of interest and the identification of therapeutic targets;
  • the evaluation and control of genomic, epigenetic and immune interactions between gene therapy vectors and the host.

INTEGRARE’s translational research is coupled with Genethon’s therapeutic programs and clinical trials.

  • COLLABORATION / CHAIRE

    INTEGRARE participates in collaborative projects and international networks.

    At Genopole:
    – The Myocapture project in partnership with France Génomique, the CEA and the CNRGH.

    In Europe:
    – Net4CGD (www.net4CGD.eu), Eurofancolen (www.eurofancolen.eu).
    – RISE Marie Sklodovska Curie Network (H2020).
    – SCIDnet consortium (including the Imagine Institute in Paris).

  • Teams

    Molecular Immunology and Biotherapy directed by GALY Anne

    Molecular Biology Laboratory of EPHE directed byPALDI Andras

    Liner Gene Transfer and Immune Tolerance directed by RONZITTI Giuseppe

    Genome Editing directed by AMENDOLA Mario

    Progressive Muscular Dystrophy directed by RICHARD Isabelle

    Neuromuscular Disorders and Gene Therapy directed by BUJ BELLO Ana

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