As France's leading biocluster, Genopole is an incubator for cutting-edge projects in biotechnology. Located in the city of Évry, just south of Paris, Genopole provides a unique environment for scientists and entrepreneurs seeking to advance research and innovation.

Discover >


Genopole accompanies researchers, postdocs and start-up entrepreneurs through all the phases of their projects to ensure the best possible conditions for business development.

Discover >

Genopole’s citizens

Every day, at Genopole, researchers, entrepreneurs and students cross paths, share ideas and unite forces in a veritable melting pot for innovation.

Discover >


Giving wings to research and empowering employment in our community are cornerstones of Genopole's mission. Catch up on recent scientific advances, the accomplishments of our biotech actors and the events that enliven the biocluster.

Discover >

Innovate with us

Discover >

GenHotel – European Research Laboratory For Rheumatoid Arthritis

Genopole Campus 2 – Building G2
2, rue Gaston-Crémieux – CP 5727
91057 EVRY Cedex – FRANCE
Phone : +33 1 60 87 45 72
Email :

Manager : PETIT-TEIXEIRA Elisabeth
Web Site >
GenHotel European Research Laboratory For Rheumatoid Arthritis - Genopole's laboratory GenHotel European Research Laboratory For Rheumatoid Arthritis - Genopole's laboratory

UEVE - Genopole's laboratory supervision #Genomics / Postgenomics #Biotherapies #Bioinformatics / Mathematics

  • Human genetics
  • Multifactorial diseases
  • Genomic variants
  • Genetic statistics
  • Computational systems biology

Field of Activity

Genomics – Genetic Statistics

Research on genetic susceptibility to complex diseases through genomic analyses with a focus on rheumatoid arthritis.

Rheumatoid arthritis, the most common autoimmune disease, is a painful chronic rheumatism that leads to progressive joint destruction. This multifactorial disease involves a large number of genetic factors, many of which have not yet been characterized.

GenHotel’s goal is to determine the multifactorial determinism of rheumatoid arthritis by studying genetic and environmental factors in patients and their families.

The final objective is to contribute to new drug target development, with a view to preventing and curing this disease.

The research methodology will be extended to other diseases having a major impact on public health. In this context, GenHotel’s activity is focused on characterization of genomic variants at risk for the studied phenotype. These sequence variants or structural variants are identified from NGS data of familial samples.

Furthermore, combination studies are performed on clinical, genomic and environmental data.

Finally, GenHotel will develop a computational systems biology approach using laboratory-produced data to characterize regulation networks.

These analyses are essential for the characterization of interactions between all the known risk factors of rheumatoid arthritis.


    GenHotel is involved in several collaborations on the Genopole campus, notably with the National Center for Research in Human Genomics (JF Deleuze, see page 34), and with the Laboratory for Mathematics and Modeling – Évry (LaMME, Genome & Statistics team).

    GenHotel is in close contact with several clinicians, notably Prof. F. Cornélis (CHU de Clermont-Ferrand), Prof. A. Finckh (HU de Genève, Suisse) and Prof. Michou (CHU Laval, Québec, Canada).

    GenHotel also develops several projects in collaborations on other autoimmune or inflammatory/ rheumatic diseases, such as ankylosing spondylitis (A Boudjema, Oran University USTO, Algeria) and Dupytren’s disease (L Michou, CHUL Quebec, Canada)

Genopole’s Laboratories

#Genomics / Postgenomics

In same field

LBEPS - Laboratoire genopolitain


LBEPS is a laboratory dedicated to the physiology and biology of exercise implementing a translation strategy from the physiology of humans in motion to the study of cellular, molecular, genetic and epigenetic responses to exercise and recovery

Inserm - Logo


ART-TG is a pre-GMP stage R&D laboratory aiming to bridge a gap between research and clinical or industrial applications. It has pharmaceutical expertise for product development and product manufacturing, specifically for genomic therapy approaches.

I-Stem - laboratoire génopolitain


The institute evaluates the therapeutic potential of all types of stem cells in the setting of monogenic diseases.

Genethon Laboratory


Gene therapy for rare genetic diseases. Research, preclinical and clinical development of gene therapies for neuromuscular and other rare genetic diseases.



Research at LGRK focuses on the homeostasis, regenerative potential and radiosensitivity of human epidermal stem cells.

Integrare - Genopole's Laboratory


The Integrare research unit aims to develop effective and safe gene therapies for rare genetic diseases such as neuromuscular disorders, metabolic diseases or blood/immune disorders

Genoscope - CNS - Genopole's laboratory

Genoscope – CNS

Genomics and postgenomics of biodiversity – Metagenomics of microorganisms from the environment.

Genoscope - CNS - Genopole's laboratory

Genomics Metabolics

The Metabolic Genomics UMR is the fundamental research structure of Genoscope – National Sequencing Center – Study of the chemistry and the diversity of organisms. Genomics of eukaryotes, prokaryotes and metagenomes.



Plant genomics. Detection, analysis and management of plant species polymorphism.

CNRGH / CEA / François Jacob Institut


The CNRGH is a national-level center whose mission is to provide high throughput genotyping and sequencing services with the objective of optimizing genetic and genomic research for human diseases.

View all >
With the support from
Région île de France