Campuses

As France's leading biocluster, Genopole is an incubator for cutting-edge projects in biotechnology. Located in the city of Évry, just south of Paris, Genopole provides a unique environment for scientists and entrepreneurs seeking to advance research and innovation.

Discover >

Advantages

Genopole accompanies researchers, postdocs and start-up entrepreneurs through all the phases of their projects to ensure the best possible conditions for business development.

Discover >

Genopole’s citizens

Every day, at Genopole, researchers, entrepreneurs and students cross paths, share ideas and unite forces in a veritable melting pot for innovation.

Discover >

Highlights

Giving wings to research and empowering employment in our community are cornerstones of Genopole's mission. Catch up on recent scientific advances, the accomplishments of our biotech actors and the events that enliven the biocluster.

Discover >

Innovate with us

Discover >
Highlights

A feat in the study of planktonic life


A Genoscope research team was part of a pioneering study in environmental genomics. From 280 billion small planktonic-DNA sequences harvested across the Earth’s oceans, the researchers were able to at least partially reconstitute the genomes of close to 700 eukaryote species. That work represents a tour de force for the large and complex genomes of these species, furthermore impossible to isolate and cultivate in the laboratory. The study, which made the cover of the 11 May 2022 edition of Cell Genomics, revealed a treasure trove of planktonic life.
Read the article >

For more than 10 years now, the plankton samples collected from across the globe by the Tara Oceans expeditions have been continuously delivering new discoveries on this vital ecosystem for the planet and humankind. For this grand scientific adventure, Genoscope sequences and analyzes the DNA found within the water samples collected from more than 150 oceanic sites and at a variety of water depths. The method used by the laboratory, called “metagenomics, has shown its potential by delivering the DNA sequences of all of the organisms present in each water sample.

Making up a large part of the many species present in plankton, eukaryotes are complex, nucleated organisms that live mainly near the ocean surface. They comprise unicellular organisms, microscopic animals and photosynthetic algae among others. By contributing greatly to the flux of matter, energy and oxygen in the ocean, eukaryotic plankton plays a key role in the stability of the entire marine ecosystem.

Compared to those of prokaryotes, the genomes of eukaryotes are larger, more complex, divided into chromosomes and marked by numerous non-coding and repetitive sequences. Because of that complexity, reconstructing individual eukaryote genomes from the global metagenome derived from oceanic water samples had remained out of science’s reach. Until now. Indeed, an international team piloted by the CNRS and Genoscope (CEA/CNRS/University of Évry-Paris Saclay) has finally touched that goal. Benefiting from the partial exclusion of prokaryotes via the size fractionation methodology available on the schooner Tara, the researchers worked on the massive amount of sequencing data from close to 800 metagenomics samples, representing 280 billion short DNA sequences. Their unprecedented results earned the cover of the 11 May 2022 edition of Cell Genomics.

From Tara Oceans to Euckaryotic plankton genomicsThe work reconstructed, at least partially, close to 700 planktonic eukaryote species genomes, and in so doing, established the most precise representation of the diversity of those species available today. The researchers were able to place the organisms into five groups sharing biological functions, one comprising multicellular species and the four others unicellular species. Surprisingly, two groups brought together taxonomically-distant organisms, demonstrating functional convergence (developing the same adaptive strategies) among species sharing a same oceanic ecosystem for millions of years. For example, similar sugar transport and metabolism functions were found in a diverse group of large eukaryotes, perhaps associated with a shared prey.

This study is a threshold-crossing first step.


Novel sequencing approaches and improved bioinformatics tools will bring even greater progress to the assembly of genomes for planktonic eukaryotes and the exploration of their genetic diversity and functions, all contributing to a better understanding of the oceans’ role in the global ecosystem.

  • What is plankton?

    Placton - Tara Océans

    The term plankton describes the collection of aquatic organisms that float passively with ocean currents, having little or no ability to swim against them. Therein are millions of different species, including viruses, bacteria, single-celled eukaryotes, microscopic algae, small crustaceans, and fish eggs and larvae among others. They constitute the first links of the oceanic food chain, produce half of the earth’s oxygen and contribute to climate stability.

  • What is metagenomics?

    The term metagenomics describes the application of genomics to the community of organisms living in a natural environment. The approach unveils the entire ecosystem in all its complexity. Metagenomics enables the single-analysis study of the collective DNA of all the microorganisms in, for example, an area of soil, the intestinal flora, human skin, or, in the present case, the oceanic plankton collected by the Tara Oceans expeditions.
    Uniting high throughput sequencing and bioinformatics, the method enables the discovery of thousands of novel genes, their functions, and even heretofore unknown species. Within the Tara Oceans expeditions, metagenomics enabled the discovery of the complex world of plankton by analyzing the DNA fragments from the community of organisms present in each sample of oceanic water.
    However, the global analysis of an environment’s DNA in this manner makes it difficult to identify and study the individual species present there, notably for large, complex genomes like those of eukaryotes.

References

Functional repertoire convergence of distantly related eukaryotic plankton lineages abundant in the sunlit ocean

Article posted on 8 June 2022

Share
Highlights

Latest news


Ynsect & Genoscope : Vers la sélection génomique des insectes d’élevage

Toward the genomic selection of farmed insects

France is historically a land of livestock farming. Cows for meat or milk, sheep, pigs, fowl of all sorts; France rears them all. And insects! With its genomic selection project for Tenebrio molitor beetles, the Genopole company Ÿnsect and its biocluster partner, the sequencing center Genoscope, are making France a pioneer in insect farming.

Discover
Logos Istem & Généthon

A two-drug combination to treat limb-girdle muscular dystrophies and cystic fibrosis

The I-Stem and Genethon laboratories have identified a promising drug combination in the setting of three genetic diseases sharing similar molecular mechanisms.

Discover
IBISC - IA qui diagnostique et explique grâce à un réseau de neurones

An artificial intelligence to diagnose and explain

The IBISC laboratory has conceived an architecturally-innovative neural network able to provide not only a diagnostic prediction but also a biological explanation.

Discover
Christophe Lanneau - Research & Platforms Department Director

News from the human genome

The 1 April edition of Science announced the publication of the human genome with the previously-missing 8% now added to it. Comments from the Genopole Director of Research.

Discover
CNRGH - Consequences of phthalate exposure during pregnancy

Consequences of phthalate exposure during pregnancy

Jörg Tost and his team of the National Center of Human Genomics Research (CNRGH; CEA) were part of a large collaborative study aimed at determining the genome-wide correlation between phthalate exposure during pregnancy and methylation of placental DNA.

Discover
INtegrare / Généthon - Efficacité à long terme de la thérapie génique d’un déficit immunitaire

Long-term efficacy for an immunodeficiency gene therapy

A gene therapy conceived by Genethon has been shown to confer long-term efficacy against Wiskott-Aldrich syndrome, an immune deficiency disorder.

Discover
I-Stem, IPSEN & LMN recreate the human muscle-nerve system

A cellular model to recreate the human muscle-nerve system

Researchers from I-Stem, IPSEN and LMN have conceived a cellular muscle-nerve model to test the therapeutic potential of botulinum toxins in vitro.

Discover
Genoscope - CNS - Genopole's laboratory

Filling the gaps in the banana’s genome

Des chercheurs de Genoscope en collaboration avec une équipe du Cirad sont parvenus à reconstituer la séquence intégrale de chromosomes de bananier.

Discover
traitement des plaies diabétiques issu de peau et d’écailles de poissons

CERITD: Treating deep wounds with fish skin

CERITD and the South Île-de-France Medical Center are testing an innovative, natural fish-skin-based treatment for diabetic foot ulcers.

Discover
SYSFATE

Sysfate Team: A tool to digitize organs

Sysfate at Genoscope has combined image analysis and genomics to create MULTILAYER, a tool to digitize biological tissues and organs.

Discover
muscle fiber

Signs of myopathy detected before muscle formation

An I-Stem team has revealed very early embryonic molecular signs of Duchenne muscular dystrophy occurring upstream of muscle development itself

Discover
Neurons representation - Cells affected by CMT

Gene therapy for Charcot-Marie-Tooth disease makes headway

A gene therapy for Charcot-Marie-Tooth disease has been shown to be efficacious in an animal-model study cosigned by a research team created through Genopole support.

Discover
LAST - Makeup by Global Bioenergies

Global Bioenergies launches its makeup brand

Interview with Marc Delcourt, founder and CEO of Global Bioenergies, launches its makeup brand : LAST

Discover
NEB France celebrate 10 years @ Genopole

New England Biolabs France Celebrates 10 Years!

Its French affiliate arrived at Genopole in 2011 and to mark its 10th anniversary in France, the company invites you to participate in monthly activities to be held throughout 2021.

Discover
Visualization and quantification by MTBench technology of protein-protein interactions observed at Opera Phenix + in a cell line.

Seeing in high resolution at the Structural Biology Platform

With the support of Genopole & the University of Évry and to enrich its technological offer, the Structural Biology Platform has acquired the Opera Phenix Plus high content screening (HCS) system.

Discover
MSCA COFUND 2020 - ApogeeBio Laureate

COFUND-MSCA2020 : ApogeeBio chosen by the EC

Submitted by Genopole and its on-site partners, the ApogeeBio project for research grants has been selected by the European Commission for Marie Skłodowska-Curie Actions co-funding (MSCA-Cofund-2020).

Discover
Genhotel -  fibroblastes, cancer & Polyarthrite

Metabolic reprogramming involved in rheumatoid arthritis and cancer

The researchers from GenHotel (University of Évry-Paris Saclay, Genopole) have shed light on certain aspects common to rheumatoid arthritis and cancer.

Discover
AB Science L. Gros

Multiple sclerosis and COVID-19: promising results from AB Science

AB Science has been announcing a series of positive results concerning the efficacy of its product, masitinib, in such pathologies as multiple sclerosis, severe asthma resistant to oral steroids, COVID-19 and amyotrophic lateral sclerosis.

Discover
Placton - Tara Oceans

Bioinformatics and Tara Oceans

A team from the Genomics Metabolics Laboratory (Genoscope – CEA/CNRS/University of Évry) has developed a bioinformatics method for environmental genomics analyses able to identify species and associations of species.

Discover
Globules rouges - Avancées scientifiques

CRISPR-Cas9 for blood and metabolic diseases – Integrare

In an article published in Nature Communications, an Integrare team headed by Dr. Mario Amendola has described an innovative genome editing strategy aimed at modifying hematopoietic stem cells.

Discover
View all >
With the support from