Campuses

As France's leading biocluster, Genopole is an incubator for cutting-edge projects in biotechnology. Located in the city of Évry, just south of Paris, Genopole provides a unique environment for scientists and entrepreneurs seeking to advance research and innovation.

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Advantages

Genopole accompanies researchers, postdocs and start-up entrepreneurs through all the phases of their projects to ensure the best possible conditions for business development.

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Genopole’s citizens

Every day, at Genopole, researchers, entrepreneurs and students cross paths, share ideas and unite forces in a veritable melting pot for innovation.

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Highlights

Giving wings to research and empowering employment in our community are cornerstones of Genopole's mission. Catch up on recent scientific advances, the accomplishments of our biotech actors and the events that enliven the biocluster.

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Platforms

Structural Biology Platform


Université d’Evry-Val-d’Essonne Bâtiment Maupertuis Rue du Père Jarlan
91025 Evry – France
Phone : +33 1 69 47 03 23
Email : llebouil@univ-evry.fr

Director : PASTRE David
Web Site >
structural analysis of a sample - Genopole platform structural analysis of a sample - Genopole platform

Host :

Laboratoire Structure et Activité des Biomolécules Normales et Pathologiques (SABNP)

#Technological Platform #Cell Biology – Microscopy #IT and Bioinformatics #Structural Biology / Chemical Analysis

  • NMR
  • 3D structures in solution
  • Modelization
  • Molecular dynamics
  • Drugs
  • Protein moieties
  • AFM
  • Molecular imaging

Supervisors:

UEVE, INSERM

Field of activity


The platform has the equipment, infrastructure and expertise necessary for the structural study of cells and biomolecules such as :
NMR & spectrofluorimetry
Molecular modeling and dynamics
Atomic Force Microscopy (AFM)

NMR & spectrofluorimetry :

  • Structure, folding, stability and dynamics of proteins in solution.
  • Ligand/protein, protein/protein, protein/nucleic acid interactions.
  • Physiopathology of the microtubule cytoskeleton, cell cycle and neuron function.

Molecular modeling and dynamics

AFM (atomic force microscopy):

  • Nanometer-scale characterization of biomolecules and complexes.
  • Air or liquid media observations of single molecules (DNA or proteins).
  • DNA-ligand / protein-protein complexes and partner microtubules.

Partnership with Synsight, a company specialized in in silico molecular modeling, for drug design and molecule safety prediction.

EQUIPMENTS

  • 600 MHz NMR spectrometer equipped with a cryoprobe.
  • Molecular modeling and molecular dynamics software.
  • Spectrofluorometer with fluorescence polarization and temperature control (MD-5020, PTI).
  • 2 Nanoscope Multimode 8 and V9 atomic force microscopes (Bruker).

ACCESS

Contacts:

  • Marie-Jeanne Lai Cheong for the NMR & spectrofluorimetry
    Phone. : +33 1 69 47 76 36 – mariejeanne.laicheong@univ-evry.fr
  • Loïc Hamon for the AFM (atomic force microscopy)
    Phone : +33 1 69 47 01 79 ou loic.hamon@univ-evry.fr
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Genopole’s Platforms

#Cell Biology – Microscopy


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