NMR & spectrofluorimetry :
- Structure, folding, stability and dynamics of proteins in solution.
- Ligand/protein, protein/protein, protein/nucleic acid interactions.
- Physiopathology of the microtubule cytoskeleton, cell cycle and neuron function.
Molecular modeling and dynamics
AFM (atomic force microscopy):
- Nanometer-scale characterization of biomolecules and complexes.
- Air or liquid media observations of single molecules (DNA or proteins).
- DNA-ligand / protein-protein complexes and partner microtubules.
Partnership with Synsight, a company specialized in in silico molecular modeling, for drug design and molecule safety prediction.
EQUIPMENTS
- 600 MHz NMR spectrometer equipped with a cryoprobe.
- Molecular modeling and molecular dynamics software.
- Spectrofluorometer with fluorescence polarization and temperature control (MD-5020, PTI).
- 2 Nanoscope Multimode 8 and V9 atomic force microscopes (Bruker).
ACCESS
Contacts:
- Marie-Jeanne Lai Cheong for the NMR & spectrofluorimetry
Phone. : +33 1 69 47 76 36 – mariejeanne.laicheong@univ-evry.fr
- Loïc Hamon for the AFM (atomic force microscopy)
Phone : +33 1 69 47 01 79 ou loic.hamon@univ-evry.fr