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As France's leading biocluster, Genopole is an incubator for cutting-edge projects in biotechnology. Located in the city of Évry, just south of Paris, Genopole provides a unique environment for scientists and entrepreneurs seeking to advance research and innovation.

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Genopole accompanies researchers, postdocs and start-up entrepreneurs through all the phases of their projects to ensure the best possible conditions for business development.

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Every day, at Genopole, researchers, entrepreneurs and students cross paths, share ideas and unite forces in a veritable melting pot for innovation.

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Giving wings to research and empowering employment in our community are cornerstones of Genopole's mission. Catch up on recent scientific advances, the accomplishments of our biotech actors and the events that enliven the biocluster.

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Highlights

Consequences of phthalate exposure during pregnancy


Jörg Tost and his team at the Epigenetic and Environment Laboratory (LEE) of the National Center of Human Genomics Research (CNRGH; CEA) were part of a large collaborative study aimed at determining the genome-wide correlation between phthalate exposure during pregnancy and methylation of placental DNA.
Publication parue dans la revue Environment International de février 2022 >

With their research partners from the Universities of Grenoble and Paris in France, and the National Center for Environmental Health and the Harvard T.H. Chan School of Public Health in the United States, the team performed its study on 202 pregnant women in the EDEN cohort and published its unprecedented results in the February 2022 edition of Environment International. The women’s exposure to phthalates was evaluated via the concentration of 11 phthalate-derived metabolites in urine samples collected between 22 and 29 weeks of pregnancy. After birth, the team studied the methylation modifications in the DNA of placental tissue. DNA Methylation (the addition of a methyl group on DNA) is the most-widely studied epigenetic* modification. Increased methylation typically represses the expression of the concerned gene. Beyond being brought about by certain pathologies, methylation modifications can also result from exposure to environmental factors such as cigarette smoke, atmospheric pollution or chemical products, among others.

The women’s exposure to phthalates was evaluated via the concentration of 11 phthalate-derived metabolites in urine samples collected between 22 and 29 weeks of pregnancy. After birth, the team studied the methylation modifications in the DNA of placental tissue. DNA Methylation (the addition of a methyl group on DNA) is the most-widely studied epigenetic* modification. Increased methylation typically represses the expression of the concerned gene. Beyond being brought about by certain pathologies, methylation modifications can also result from exposure to environmental factors such as cigarette smoke, atmospheric pollution or chemical products, among others.

In conclusion


Some diseases manifesting in adulthood may find their origins in the earliest stages of life, including the prenatal period. This study suggests that fetal exposure to environmental compounds like phthalates could affect development via epigenetic modifications.

  • * Epigenetics

    The term epigenetics describes the range of inheritable phenomena able to modify gene expression without modifying the DNA sequence itself.
    For example, the cells of any one organ are very different from those of another despite their identical DNA. This is possible because the genes expressed in one differ from those expressed in the other, and that difference in gene expression is maintained in cell division.
    Epigenetics can be considered as a sort of molecular memory physically associated with the chromosome. Although less stable than genetic mutations, epigenetic factors are transmitted across several generations.
    Nutrition, stress, temperature, tobacco exposure and even infections can cause epigenetic modifications. Epigenetics is thus, in a certain manner, the dynamic aspect of the genome, giving it a capacity for rapid environmental adaptation. Its mechanisms are flexible and reversible but also complex. Research continues to advance knowledge on the role of epigenetics in a range of diseases including cancer.

Référence

Pregnancy exposure to phthalates and DNA methylation in male placenta — An epigenome-wide association study

Environment International Volume 160, February 2022
https://doi.org/10.1016/j.envint.2021.107054

Article posted on 15 March 2022

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News


Ynsect & Genoscope : Vers la sélection génomique des insectes d’élevage

Toward the genomic selection of farmed insects

France is historically a land of livestock farming. Cows for meat or milk, sheep, pigs, fowl of all sorts; France rears them all. And insects! With its genomic selection project for Tenebrio molitor beetles, the Genopole company Ÿnsect and its biocluster partner, the sequencing center Genoscope, are making France a pioneer in insect farming.

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Couverture de la revue Cell Genomics - Le plancton

A feat in the study of planktonic life

A Genoscope research team was part of a pioneering study in environmental genomics. The researchers were able to at least partially reconstitute the genomes of close to 700 eukaryote species.

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Logos Istem & Généthon

A two-drug combination to treat limb-girdle muscular dystrophies and cystic fibrosis

The I-Stem and Genethon laboratories have identified a promising drug combination in the setting of three genetic diseases sharing similar molecular mechanisms.

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IBISC - IA qui diagnostique et explique grâce à un réseau de neurones

An artificial intelligence to diagnose and explain

The IBISC laboratory has conceived an architecturally-innovative neural network able to provide not only a diagnostic prediction but also a biological explanation.

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Christophe Lanneau - Research & Platforms Department Director

News from the human genome

The 1 April edition of Science announced the publication of the human genome with the previously-missing 8% now added to it. Comments from the Genopole Director of Research.

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INtegrare / Généthon - Efficacité à long terme de la thérapie génique d’un déficit immunitaire

Long-term efficacy for an immunodeficiency gene therapy

A gene therapy conceived by Genethon has been shown to confer long-term efficacy against Wiskott-Aldrich syndrome, an immune deficiency disorder.

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I-Stem, IPSEN & LMN recreate the human muscle-nerve system

A cellular model to recreate the human muscle-nerve system

Researchers from I-Stem, IPSEN and LMN have conceived a cellular muscle-nerve model to test the therapeutic potential of botulinum toxins in vitro.

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Genoscope - CNS - Genopole's laboratory

Filling the gaps in the banana’s genome

Des chercheurs de Genoscope en collaboration avec une équipe du Cirad sont parvenus à reconstituer la séquence intégrale de chromosomes de bananier.

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traitement des plaies diabétiques issu de peau et d’écailles de poissons

CERITD: Treating deep wounds with fish skin

CERITD and the South Île-de-France Medical Center are testing an innovative, natural fish-skin-based treatment for diabetic foot ulcers.

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SYSFATE

Sysfate Team: A tool to digitize organs

Sysfate at Genoscope has combined image analysis and genomics to create MULTILAYER, a tool to digitize biological tissues and organs.

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Signs of myopathy detected before muscle formation

An I-Stem team has revealed very early embryonic molecular signs of Duchenne muscular dystrophy occurring upstream of muscle development itself

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Neurons representation - Cells affected by CMT

Gene therapy for Charcot-Marie-Tooth disease makes headway

A gene therapy for Charcot-Marie-Tooth disease has been shown to be efficacious in an animal-model study cosigned by a research team created through Genopole support.

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LAST - Makeup by Global Bioenergies

Global Bioenergies launches its makeup brand

Interview with Marc Delcourt, founder and CEO of Global Bioenergies, launches its makeup brand : LAST

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NEB France celebrate 10 years @ Genopole

New England Biolabs France Celebrates 10 Years!

Its French affiliate arrived at Genopole in 2011 and to mark its 10th anniversary in France, the company invites you to participate in monthly activities to be held throughout 2021.

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Visualization and quantification by MTBench technology of protein-protein interactions observed at Opera Phenix + in a cell line.

Seeing in high resolution at the Structural Biology Platform

With the support of Genopole & the University of Évry and to enrich its technological offer, the Structural Biology Platform has acquired the Opera Phenix Plus high content screening (HCS) system.

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MSCA COFUND 2020 - ApogeeBio Laureate

COFUND-MSCA2020 : ApogeeBio chosen by the EC

Submitted by Genopole and its on-site partners, the ApogeeBio project for research grants has been selected by the European Commission for Marie Skłodowska-Curie Actions co-funding (MSCA-Cofund-2020).

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Genhotel -  fibroblastes, cancer & Polyarthrite

Metabolic reprogramming involved in rheumatoid arthritis and cancer

The researchers from GenHotel (University of Évry-Paris Saclay, Genopole) have shed light on certain aspects common to rheumatoid arthritis and cancer.

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AB Science L. Gros

Multiple sclerosis and COVID-19: promising results from AB Science

AB Science has been announcing a series of positive results concerning the efficacy of its product, masitinib, in such pathologies as multiple sclerosis, severe asthma resistant to oral steroids, COVID-19 and amyotrophic lateral sclerosis.

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Placton - Tara Oceans

Bioinformatics and Tara Oceans

A team from the Genomics Metabolics Laboratory (Genoscope – CEA/CNRS/University of Évry) has developed a bioinformatics method for environmental genomics analyses able to identify species and associations of species.

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Globules rouges - Avancées scientifiques

CRISPR-Cas9 for blood and metabolic diseases – Integrare

In an article published in Nature Communications, an Integrare team headed by Dr. Mario Amendola has described an innovative genome editing strategy aimed at modifying hematopoietic stem cells.

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