Hybrigenics Services

#R&D Services and Products #Biomanufacturing / Pharmaceutical Services

• Protein interactions
• Drug target deconvolution
• Molecular glues
• Nanobodies

BACKGROUND
Launched in 1998 as Hybrigenics SA, a first spin-off from Institut Pasteur Paris, the company optimizes a yeast two-hybrid system for protein-protein interaction discovery. Its services activities were launched in 2003. Hybrigenics Services has developed new versions for drug discovery (2013, mechanism of action; 2019 molecular glues/PROTACs). A novel nanobody selection platform was launched in 2016.
The company is an independent entity since 2017.
DESCRIPTION OF THE PRODUCTS / SERVICES / TECHNOLOGY
Hybrigenics Services has technological platforms for the:

• discovery of novel protein-protein interactions, Protein network (ULTImate Y2H™)
• identification of small molecule interactions, e.g., proteins, their therapeutic targets, elucidation of mechanisms of action for drug candidates (ULTImate YChemH™)
• identification of PPIs induced by small molecules (molecular glues, PROTACs, etc.) for targeted protein degradation (TPD) & stabilization projects (ULTImate Y2HChem™)
• selection and validation of VHH antibodies (HYBRIBODY™)

CUSTOMER REFERENCES / COLLABORATIONS / HIGHLIGHTS

• The company counts 3,000 clients and partners across the globe and the spectrum of scientific domains (pharma, agriculture, cosmetics, basic research). Biotechs from start-ups to large corporations in pharma and agriculture, academic research.
• Hybrigenics Services has established scientific and technological renown with more than 500 publications on its results in top-ranked journals
• Hybrigenics Services completes more than 150 mostly confidential service contracts yearly, with pricings ranging from several thousand to several hundred thousand euros

PARTNERSHIPS SOUGHT
Hybrigenics Services seeks partnerships with biotechs, start-ups, the pharmaceutical industry, and actors in agricultural sciences and academic research.

• Further Information

  2 Patents
  30 Staff Members
  Strengths:

  • Field-leading Y2H screening platform with a very large collection (130) of cDNA libraries (45 species: human, animals, plants, model organisms, bacteria, etc.), exhaustive screening and integrated bioinformatics.
  • Nanobodies: Animal-free technique to select synthetic VHH antibodies from a patented bank of 3X10⁹ humanized camalid VHHs.
  • 25 years of experience
  • 10,000 Y2H and associated screenings

  Innovation Assets:
  Continuously listening to the needs of researchers to bring them new, pertinent solutions.
  Other facts:
  Hybrigenics Services is a private, management/employee-owned company. It practices corporate social responsibility. Hybrigenics Services measured its carbon footprint in 2021 and deployed specific actions to reduce its environmental impact.