LAMBE – Analysis, Modeling, Materials for Biology and the Environment

#Biophysics / Biochemistry #Nanotechnologies #Biomaterials

• Mass spectrometry (MS)
• Biomolecule modeling and simulation
• Proteomic analyses
• Development of new analytical strategies (MS / separation techniques coupling)
• Electrochemistry
• Corrosion Electrochemical sensor development
• Macromolecular chemistry
• Supramolecular assemblies
• Macro and supramolecular synthesis of biosourced materials
• Membrane transport
• Natural and synthetic nanopores
• Gene therapy
• Extracellular matrix and the cellular microenvironment

Supervisors:

The LAMBE is a mixed CNRS-UEVE-CYU unit. His research themes mainly concern the structure / reactivity of biomolecules, the interaction of complex molecular assemblies, the reactivity to the interfaces in the environment and the polymeric materials at the interfaces.

The 4 research team work in the following areas:

• Proteomic studies (analysis of post-translational modifications, immunopurified protein complexes, etc.) by using MALDI/TOF, electrospray/Q/TOF, capillary electrophoresis/ion trap/ETD and LTQ orbitrap/ETD mass spectrometers.
• Development of new capillary electrophoresis/ surface plasmon resonance (SPR)/mass spectrometry coupling.
• Study of the role of metal cations in the catalysis and activation of model biological compounds (amino acids, nucleotides, saccharides, etc.) in the gaseous phase.
• Multiscale modeling of the structure and function of biological assemblies.
• Development of course-grained force fields via protein-protein binding.
• Prediction and modeling of the long-term behavior of final electronuclear waste.
• Study of the transport (translocation) of single macromolecules through nanometer-scale protein-based pores and artificial biomimetic pores (nanolithography).
• Development of electrochemical sensors and biosensors for pollutant analyses.
• Synthesis of polymer gene therapy vectors and analysis of their in vitro and in vivo structure and function.
• Synthesis of biosourced polymers.
• Synthesis of self-healing materials.

• COLLABORATION / CHAIR

  – Arcelor.
  – Synchrotron Soleil.
  – Ceva (Centre d’Etude et de Valorisation des Algues).
  – Global Bioenergies.
  – Horiba Jobin Yvon.
  – GeneSignal.
  – LFB.
  – Polytheragene.

• TEAMS

  – Structure-réactivité de biomolécules : Complexes Organométalliques et Macromoléculaires dirigé par Florence Gonnet et Régis Daniel

  – Interaction des Assemblages Moléculaires complexes : Théorie et Modélisation dirigé par Marie-Pierre Gaigeot

  – Réactivité aux interfaces dans l’Environnement dirigé par Ludovic Legrand

  – Matériaux Polymères aux Interfaces dirigé par Nathalie Jarroux et Juan Pelta