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AGS Therapeutics

5 Rue Henri Desbruères
Campus 1
91030 Évry-Courcouronnes Cedex – FRANCE

Contact: hello@ags-tx.com

Manuel VEGA, CEO – Founder
Lila DRITTANTI, COO – Founder
Marie-Hélène LEOPOLD, Chief Corporate Development Officer – Founder
Web Site >
AGS Therapeutics - log AGS Therapeutics - log

#Health & well-being #Therapeutics

  • MEVs – microalgae Extracellular Vesicles
  • Delivery System for Human Therapeutics
  • Vaccines
  • Gene Therapy

Field of activity

AGS Therapeutics is a biotech company pioneering the use of microalgae extracellular vesicles (MEVs) as a universal delivery system for innovative therapeutics, vaccines and gene therapies.

Background

AGS Therapeutics results of 10+ years of research on siRNA and plant EVs. A pioneer work by Lionel Navarro’s team, CNRS/Ecole Normale Supérieure, specialized on plant immunity against phytopathogens, with an initial patent filed by CNRS showing that EVs produced by plants or microalgae can be internalized by human cells as well as by bacterial cells, thus showing their potential to be used as a vehicle for biologically active compounds.

Description of the Products / Services / Technology

AGS technology platforms (including MEV technology plus payload design and discovery) are a steady source of candidate products.
AGS’s more advanced products include:

  • AGS-1010 (ophthalmology), a candidate product intended for the treatment of neovascularization, including wAMD, by eye drops (technological breakthrough). Delivery system: MEVs. Payload : anti-angiogenic molecule. Target tissue : choroid and retinal cells.
  • AGS-2010 (immunomodulation), a candidate product intended for the treatment of a bowel disease, by oral administration. Delivery system: MEVs. Payload : modulator of endosomal TLR9. Target tissue : enterocytes, intestinal resident macrophages.
    • Further information

      8 Pending patent families
      8 Staff members

      Strengths
      AGS-M, the company’s CDMO subsidiary, produces the MEVs needed to support R&D from AGS and from companies partnering with AGS.
      Innovation assets
      AGS has shown MEVs to be a safe, targeted and highly versatile delivery system for mRNA, siRNA, DNA oligos, plasmids, proteins, and peptides relevant to a broad range of human diseases.
      Other facts
      AGS’ MEVs are derived from Chlorella, a two-billion-year-old single-cell algae, labeled by the FDA as GRAS for consumption as a food supplement.

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    With the support from
    Région île de France
    Ministère de l'Enseignement supérieur et de la recherche AFM-Téléthon
    Communauté d'agglomération Grand Paris Sud
    Département de l'Essonne - Terre D'avenirs Ville d'Evry-Courcouronnes 2023 CEA Inserm Centre hospitalier Sud Francilien Université d'Evry - Paris Saclay Université PAris-Saclay SEM Genopole

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