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As France's leading biocluster, Genopole is an incubator for cutting-edge projects in biotechnology. Located in the city of Évry, just south of Paris, Genopole provides a unique environment for scientists and entrepreneurs seeking to advance research and innovation.

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Platforms

PBPK Modeling Platform


Phinc Development Bâtiment 8 Genopole Campus 1 5, rue Henri Desbruères
91030 Evry – France
Phone : +33 1 60 87 35 15
Email : plates-formes@genopole.fr

Director : ORLANDINI Bernard
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Host:

Phinc Development

#Software Platform #IT and Bioinformatics

  • Modeling and simulation
  • Physiologically-based
  • pharmacoKinetic modeling – PBPK
  • Lead
  • Drugs
  • Preclinical and clinical development

Supervisor:

Phinc Development

Field of activity


Computerized pharmacokineticpharmacodynamic modeling and simulation platform for the optimization of drug development during lead identification, preclinical testing and phase I and IIa trials.

GastroPlus is a simulation software package that permits the construction of specific biomathematical models for therapeutic compounds in accordance with current knowledge in physiology, anatomy, physics and chemistry. Its modeling capacities evolve as new data is obtained (physico-chemical, in vivo, animal model, clinical, etc.). With its multidisciplinary and iterative approach, GastroPlus brings vital added value to:

  •  lead selection or development
  • preclinical interspecies extrapolation
  • the move from preclinical studies to clinical trials: human ADME prediction, selection of first-in-man dose, regimen and route of administration
  • the evaluation of drug or food interactions.

The GastroPlus approach thus optimizes the drug development research path. Health agencies, recognizing the contribution of PBPK modeling to drug development, are currently creating a framework for its use in regulatory files, with an initial focus on drug interactions, formulation optimization and investigations in special populations.

Equipments

GastroPlus software and modules:

  • PBPK Plus
  • ADMET Predictor
  • Additional Dosage Routes
  • Drug Drug Interaction
  • Metabolism and Transporter Module
  • Ocular Module
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