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PBPK Modeling Platform

Phinc Development Bâtiment 8 Genopole Campus 1 5, rue Henri Desbruères
91030 Evry – France
Phone : +33 1 60 87 35 15
Email :

Director : ORLANDINI Bernard
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Phinc Development

#Software Platform #IT and Bioinformatics

  • Modeling and simulation
  • Physiologically-based
  • pharmacoKinetic modeling – PBPK
  • Lead
  • Drugs
  • Preclinical and clinical development


Phinc Development

Field of activity

Computerized pharmacokineticpharmacodynamic modeling and simulation platform for the optimization of drug development during lead identification, preclinical testing and phase I and IIa trials.

GastroPlus is a simulation software package that permits the construction of specific biomathematical models for therapeutic compounds in accordance with current knowledge in physiology, anatomy, physics and chemistry. Its modeling capacities evolve as new data is obtained (physico-chemical, in vivo, animal model, clinical, etc.). With its multidisciplinary and iterative approach, GastroPlus brings vital added value to:

  •  lead selection or development
  • preclinical interspecies extrapolation
  • the move from preclinical studies to clinical trials: human ADME prediction, selection of first-in-man dose, regimen and route of administration
  • the evaluation of drug or food interactions.

The GastroPlus approach thus optimizes the drug development research path. Health agencies, recognizing the contribution of PBPK modeling to drug development, are currently creating a framework for its use in regulatory files, with an initial focus on drug interactions, formulation optimization and investigations in special populations.


GastroPlus software and modules:

  • PBPK Plus
  • ADMET Predictor
  • Additional Dosage Routes
  • Drug Drug Interaction
  • Metabolism and Transporter Module
  • Ocular Module
Genopole’s Platforms

#IT and Bioinformatics

In same field

REVE - Infrastructure Genopole

High-Speed Network – REVE

REVE links 14 scientific sites in the Grand Paris Sud Urban Area and is available to companies based on the Évry-Corbeil biocluster. It provides rapid access to genetics and genomics data. A private telecom network in Évry.

Plateforme MicroScope -


The MicroScope platform is an integrative resource that supports systematic and efficient revision of microbial genome annotation, data management and comparative analysis.

Ibisc - Genopole's Laboratory

Platform EVRYRNA

The Evrynna platform is a web server providing various algorithms and bio-computing tools developed in the UEVE / Genopole Ibisc laboratory, and dedicated to the prediction and analysis of non-coding RNAs (CRMA).

Ibisc - Genopole's Laboratory

EVR@ Platform

Platform dedicated to virtual reality, the creation of collaborative, immersive interfaces …

SABNP - Genopole's laboratory

Structural Biology Platform

The platform has the equipment, infrastructure and expertise necessary for the structural study of cells and biomolecules

occigen - plateforme genopolitaine

Imaging & Cytometry Platform – OCCIGEN

Expertise and tools for molecular and physiopathological exploration, from the single cell to the entire living organism via imaging and flow cytometry techniques.

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